Welcome to circ2GO

Thousands of circular RNAs (circRNAs) are expressed in eukaryotic cells. Here, we provide a dataset of circRNA expression for 148811 circRNAs based on 3.5 billion sequencing reads of rRNA-depleted RNA derived from 60 human lung cell lines including 50 lung adenocarcinoma (LUAD) cell lines. Additionally, the circRNA expression data is merged with orthogonal data about gene and transcript information, functional annotation by gene ontology and microRNA binding site prediction.

In circ2GO, you can explore the circRNA profiles, visualize circRNAs expressed from each gene and differentially spliced transcript, view the gene ontology annotation and microRNA binding sites for each circRNA and download the respective data. Most importantly, reverse searches allow the search for circRNAs derived from genes with certain biological processes, molecular functions or cellular components assigned by gene ontology or possessing specific microRNA binding sites to discover circRNAs in the areas of your interest.



Genes

12251

circRNAs

148811





References

The Circular RNA Landscape of Non-Small Cell Lung Cancer Cells. Nele Van Der Steen et al. Cancers 2020.














About circ2GO

How to cite

The Circular RNA Landscape of Non-Small Cell Lung Cancer Cells. Nele Van Der Steen et al. Cancers 2020.

circ2GO: A database linking circular RNAs to gene function. Yanhong Lyu et al. Cancers 2020.



Contact

The authors of the circ2GO database can be contacted at the following email address

databases.diederichslab(at)dkfz.de

Version 1.1



circRNA Transcript Map


Gene Information


circRNA Heatmap


Gene Information


Download Sum     Download Cell Lines    


GO Search

Basic search

Searching genes by entering a complete GO term

   

Advanced search

 AND 
 

Step 1: Searching for a GO term by entering 2 key words
Step 2: Searching genes by selecting a GO term from table generated below

   

circMap/Heatmap/Download for selected gene:


                      

                    

                    

                      

                        
                           
                        
                           
                      

                    

                  

                

              

            

            

            

          

          

            
circRNA-miRNA Search

            

              

                

                  

                    
                    

                      
                      
                    

                    

                    

                      
                         
                      
                      

                      

                      
                      

                    

                  

                

              

            

            

              

              

                

                  

                    
circMap/Heatmap/Download for selected gene:

                    

                    

                      
                         
                      
                    

                  

                

              

            

            

            

            

            

            

            

            

            

          

          

            
Download circRNA Data by cell lines

            

              

                

                  

                    

                      
                      

                        
                        

                          
                          
                        

                      

                    

                    

                      

                        
                        

                          

                            
                          

                          

                            
                          

                        

                      

                    

                    

                      
                        
                        Download data
                      
                    

                    

                    

                  

                

              

            

            
Download circRNA Data by genes

            

              

                

                  

                    

                      
                      
                    

                    

                    

                      

                        
                        

                          

                            
                          

                          

                            
                          

                        

                      

                    

                    

                      
                        
                        Download data
                      
                    

                    

                    

                  

                

              

            

            
Download miRNA Data

            

              

                

                  

                    

                      
                      
                    

                    

                    

                      
                        
                        Download data by IDs
                      
                         
                      
                        
                        Download all data
                      
                    

                    

                    

                  

                

              

            

            

            

            

          

          

            

              

                

                  Help and Documentation
                

              

            

            

              

                

                  

                  

                    

                      
  • circ2GO is a database that provides a comprehensive circRNA expression profiles for 60 human cell lines comprising 50 lung adenocarcinoma (LUAD), seven non-LUAD non-small cell lung cancer (NSCLC) and three non-transformed lung cell lines. Importantly, the circ2GO data was derived from 3.5 billion RNA-seq reads from rRNA-depleted RNA and hence not biased due to polyA enrichment.
                                                    

                    

                  

                  

                    

                      
  • The circRNA Search option can be used to search the database for circRNA expression profiles of a single gene. The circRNA Transcript Map visualizes the location and expression of all circRNAs on all transcripts of the respective gene. The circRNA Heatmap depicts the circRNA read counts in each cell line. Hovering with the mouse over the heatmap gives the read count value (normalized to library size) and cell line name. The read count data shown in the heatmap can be downloaded as a CSV file.
                                                    

                    

                  

                  

                    

                      
  • The GO Search option allows the search of the database for the gene ontology terms assigned to the gene from which the circRNA is derived. Thereby, the user can search for circRNAs potentially linked to the biological process, molecular function or cellular component of interest. For the resulting list of circRNAs, a transcript map and heatmap can be obtained.
                                                    

                    

                  

                  

                    

                      
  • The circRNA-miRNA search  option provide a database of  circRNA-miRNA pairs predicted by TargetScan  and miRanda. It covers 897 high-confidence human miRNAs from miRbase and 25166 high abundant circRNAs from our circRNA database. circRNA ID/gene ID/gene name/MiRbase ID/miRNA family ID can be used for searching predicted circRNA-miRNA pairs, fuzzy search is supported.

                    

                  

                  

                    

                      
  • With the Data Download option, batch searches for cell lines or genes can be carried out and the resulting datasets can be downloaded as CSV files.

                    

                  

                  

                  

                

              

            

          

        

        

          

            

              

                

              

            

            

              

                
                      
                  © 2020 - 
                  (
                  Diederichs Lab/Projects - DKFZ Heidelberg
                  )